IL-23 tees off enthesitis
نویسندگان
چکیده
منابع مشابه
Macrophage in Enthesis: A Likely Contributing Factor to Enthesitis through IL-23 in Ankylosing Spondylitis
Ankylosing Spondylitis (AS) is a chronic inflammatory disease that characterized by enthesitis and subsequent syndesmophytes in spinal joints and peripheral joints. However, the exact pathogenesis of AS is still unknown. Recent studies indicate that serum concentrations of interleukin-23 (IL-23) are elevated in AS and the expression of IL-23 in vivo is sufficient to phenocopy the human disease ...
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15 صفحه اولSerum interleukin-23 (IL-23) is increased in Hashimoto's thyroiditis.
Recent studies have demonstrated that T-helper 17 lymphocytes (Th17), which produce mostly IL-17, play a major role in several autoimmune diseases commonly thought to be Th1-related, including Hashimoto's thyroiditis (HT). IL-23, a member of the IL-12 cytokine family, is known to guide T cells toward the Th17 phenotype and its serum levels are increased in several autoimmune disease. Few data a...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2012
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri3269